Ameliorative effects of Hesperidin on radiation induced brain injury in rats

نویسندگان

  • A. Kale Department of Neurosurgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
  • B.G. Aydın Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine,Zonguldak, Turkey.
  • Ç. Büyükuysal Department of Biostatistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
  • M. Can Department of Biochemistry, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
  • Ö. Elmas Department of Radiation Oncology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
  • Ö. Pişkin Department of Anesthesiology and Reanimation, Bülent Ecevit University Faculty of Medicine,Zonguldak, Turkey.
  • Y. Baş Department of Pathology, Hitit University Faculty of Medicine, Çorum, Turkey
چکیده مقاله:

Background: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (control, hesperidin, radiation, and radiation+hesperidin groups; 8 rats in each group). 200 mg/kg  doses of hesperidin were administered to the animals in the hesperidin and radiation+ hesperidin groups, radiation and radiation+ hesperidin groups were exposed to a dose of 20 Gy cranium region. Tissue samples, and biochemical levels of tissue injury markers in four groups were compared. Results: In all measured parameters of oxidative stress, administration of hesperidin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated significant decrease in cellular degeneration and infiltration parameters after hesperidin administration. Conclusion: This Hesperidin demonstrated significant neuroprotection after radiation induced brain injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Ameliorative effects of silymarin on HCl-induced acute lung injury in rats; role of the Nrf-2/HO-1 pathway

Objective(s): Aspiration is a common cause of acute lung injury (ALI), which lacks an effective treatment. Inflammation and oxidative stress play key roles in ALI development. Silymarin is an active extract of Silybum marianum plant seeds (milk thistle). Silymarin has potent anti-inflammatory and antioxidant effects; however its role in aspiration induced ALI has not b...

متن کامل

Radio-protective effects of Hesperidin against gamma radio-radio-protective effects of Hesperidin against gamma radiation induced histopathological changes in the liver of Sprague Dawely rats

Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to ...

متن کامل

Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats

This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formaldehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant r...

متن کامل

The Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats

Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 17  شماره 2

صفحات  229- 236

تاریخ انتشار 2019-04

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023